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This shows that the use of unnatural stereochemistry in GSH is unlikely to prevent the substantial first-pass metabolism by GGT in the liver for orally administered GSH, and it is also unlikely to aid in improving its oral bioavailability [31]

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Specifically, oscillations in H2B monoubiquitination have been associated with the transcriptional cycling of circadian genes, such as PER1 and PER2, indicating that chromatin remodeling through histone ubiquitination is closely aligned with the molecular clock (Tamayo et al., 2015)

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Hehn, Rebecca Simonne